Catalyzes the formation of 5(S)-HpETE from arachidonic acid as well as its subsequent conversion to leukotriene A4; localized in the cytosol of resting human and rat peripheral blood neutrophils or in the nucleus in rat basophilic leukemia cells and human alveolar macrophages; translocates to the nuclEAr membrane to associate with FLAP upon cell stimulation. Technical Information Synonyms Arachidonate 5-lipoxygenase 5-LO 5-LOX Source Active recombinant human protein expressed in insect cells MW 78 kDa Formulation A clarified lysate, in 100 mM Tris-HCl, pH 8.0, containing 5 mM EGTA, 1mM CaCl2, and 30% glycerol Enzyme Commission 1.13.11.34 UniProt Accession P09917