ApoA1 is a major protein component in high-density lipoproteins (HDLs). It acts as an acceptor for sequential transfers of phospholipids and free cholesterol from peripheral tissues and transports cholesterol to the liver and other tissues for excretion and steroidogenesis.1 Serum ApoA1 levels are inversely related to the risk of developing atherosclerosis.2 Loss-of-function mutations are causes of diseases such as HDL deficiency type 1 (or Tangier disease) and type 2 (familial hypoalphalipoproteinemia), and systemic non-neuropathic amyloidosis.3,4 ApoA1 is comprised of a single polypeptide chain of 243 amino acids residues with an estimated molecular weight of 28 kDa. Caymans ApoA1 Polyclonal Antibody (Item No. 10008463) detects the protein by western blot analysis in tissue/cell samples such as liver, intestine, and HepG2 cells.