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JMJD2D Strep-tagged (human recombinant)

JMJD2D Strep-tagged (human recombinant)

₹ 44,880.00 *
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  • Brand: Cayman Chemical
  • Catalog No.: 11300
  • Quantity/Unit: 100 ug/Pack
  • Shipping timeline will be mentioned in quote

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Min Orderable Qty : 1 Pack


For lab/research use only, unless otherwise specified

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Methylation of lysine residues in core histones plays a critical role in regulating gene expression.1 Jumonji domain containing 2D (JMJD2D) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me 2/3), lEAding to transcriptional repression and activation, respectively.2 Like other JmjC protein hydroxylase family members, JMJD2D is an -ketoglutarate-dependent Fe (II) oxygenase.3 Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decrEAsed activity, therefore this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin.4 Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents.1Technical InformationSynonymsJumonji Domain Containing 2DKDM4DLysine-specific Demethylase 4DPurity70% estimated by SDS-PAGESourceactive recombinant N-terminal Strep II-tagged protein expressed in E. coliMW42.6 kDaFormulation20 mM HEPES, pH 7.4, and 150 mM sodium chlorideLicenseSold under license from IBA.UniProt Accession Q6B0I6