Uricase (UA) is supplied by the company, Akon Scientific.

Uricase or urate oxidase is a hepatic enzyme meaning it is located in the liver and converts uric acid into allantoin. Allantoin is more efficiently excreted by the kidney because of how water soluble it is. However, in humans, a frameshift mutation during evolution affected the activity of the gene that encodes for uricase. It is an enzyme that converts uric acid to allantoin. Allantoin is much more soluble than uric acid, and passes harmlessly from the body. Unfortunately, during evolution, humans have lost the ability to produce uricase. The detailed mechanism consists of a copper binding enzyme catalyzing the oxidation or uric acid to 5-hydroxyisourate and hydrogen peroxide followed by the hydrolysis and decarboxylation leading to the formation of the desired product, allantoin.

Product specifications:

• Catalog number: HH0905
• Brand: Akon Scientific
• Quantity/unit: Pack of 5KU