To be used in conjunction with Caymans Adipose Triglyceride Lipase polyclonal antibody (Catalog No. 10006409) to block protein-antibody complex formation during immunochemical analysis of adipose triglyceride lipase protein. Triglycerides are the most efficient form of energy storage in mammalian adipose tissue during times of caloric excess. ATGL is one of the key enzymes involved in the mobilization of fatty acids from triglyceride stores in adipose tissue, catalyzing the conversion of triacylglycerols to diacylglycerols.1 Inhibition of ATGL markedly decrEAses total adipose acyl-hydrolase activity, and thus may be a potential drug target for the diabetic pathology.1 ATGL mRNA is detected in a wide range of tissues including adipose, lung, skeletal muscle, testis, hEArt, brain, and kidney, with adipose tissue expressing the highest level.2 Human ATGL is 504 amino acids in length with an estimated molecular weight of 55.2 kDa. Caymans ATGL polyclonal antibody detects the enzyme at 56 kDa by western blot from tissues and cells such as brown fat, liver, murine macrophages, and HepG2 cells. Technical Information Synonyms ATGL Desnutrin TG-hydrolase inducible PLA2- PNPLA2 Amino Acids human adipose triglyceride lipase (ATGL) protein amino acids 382-400 (KRKLGRHLPSRLPEQVELR) Formulation 200 ug of peptide in 200 l TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide