CdnP (Mycobacterium tuberculosis strain ATCC 25618/H37Rv recombinant)
- Brand: Cayman Chemical
- Catalog No.: 22809
- Quantity/Unit: 100 ug/Pack
- Shipping timeline will be mentioned in quote
Min Orderable Qty : 1 Pack
For lab/research use only, unless otherwise specified
Cyclic di-nucleotide phosphodiesterase (CdnP, also known as Rv2837c) is a soluble, stand-alone phosphodiesterase in regulating cyclic dinucleotide signaling during intracellular infections of M. tuberculosis1. Studies have found that CdnP is capable of hydrolyzing cyclic di-adenosine monophosphate (c-di-AMP; Item No. 17753) into two AMPs as a strategy to avoid activation of the innate immune response of the host. M. tuberculosis infection lEAds to cytosolic relEAse of c-di-AMP, which is recognized by stimulator of interferon genes (STING) and subsequently triggers type I interferon response.2 Other studies have shown that deletion or inhibition of CdnP attenuates the M. tuberculosis virulence both in vitro and in vivo.3,4Technical InformationSynonymsBifunctional OligoribonuclEAse and PAP Phosphatase NrnA3'(2'),5'-Bisphosphate NucleotidaseCyclic di-NMP PhosphodiesteraseEC: 31.13.7PAP Phosphatase3'-Phosphoadenosine 5'-phosphate PhosphataseRv2837cPurity70% estimated by SDS-PAGESourceN-terminal Trx-tagged, His-tagged, and S-tagged M. tuberculosis cyclic di-NMP phosphodiesterase protein (full length) purified from E. coliAmino Acids1-336 (full length)MW52.71 kDa (includes purification tag)Formulation50 mM HEPES, pH 8, containing 150 mM sodium chlorideUniProt Accession P71615