Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells.1 It is subject to citrullination by peptidyl arginine deiminase 2 (PAD2; Item No. 10785) under high calcium concentrations, which can occur during macrophage apoptosis.2 Citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs).2,3 ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune disEAses.3Technical InformationPurity55 %SourceHuman recombinant vimentin purified from E. coliAmino Acids2-466MW53.5 kDaFormulation10 mM Tris, pH 8.0UniProt Accession P08670