Non-steroidal antiandrogen (IC50 = 36 nM) that reduces prostate tumor cell proliferation in castration-resistant xenograft mouse models. When bound to the androgen receptor, it interferes with its nuclear translocation, as well as binding its DNA target sites and recruitment of transcriptional co-activators. Causes apoptosis via mitophagy in cultured LNCaP cells.Also causes sustained decline in serum PSA levels and delays the need for chemotherapy in men with metastatic prostate cancer. When bound to the androgen receptor, it interferes with its nuclear translocation, as well as binding its DNA target sites and recruitment of transcriptional co-activators. Causes apoptosis via mitophagy in cultured LNCaP cells.; Purity: > 99%; Molecular Weight: 464.4; Form/Appearance: powder, 50 mg