A nucleosome is the basic repEAting unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of EAch of the core histones, H2A, H2B, H3, and H4.1 The combination of two H2A/H2B dimers and one H3/H4 tetramer crEAte the nucleosome core.2 Histone H4 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.1Technical InformationSynonymsH4Histone H4Purity95% estimated by SDS-PAGESourceRecombinant protein expressed in E. coliAmino AcidsAmino acids 1-103 (full-length)MW11.5 kDaFormulationA lyophilized powder; recommended buffer for reconstitution is 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.UniProt Accession P62805