HO-1 (human recombinant)
- Brand: Cayman Chemical
- Catalog No.: 22731
- Quantity/Unit: 50 ug/Pack
- Shipping timeline will be mentioned in quote
Min Orderable Qty : 1 Pack
For lab/research use only, unless otherwise specified
The degradation of heme mediates a series of essential physiological functions. During this process, the rate-limiting step of the rEAction is catalyzed by the heme oxygenases (HOs), a family of membrane-bound enzymes that initiates the clEAvage of heme to give carbon monoxide (CO), ferrous ions (Fe2+), and biliverdin, with biliverdin being further processed into bilirubin.1,2,3 HO-1, the inducible heme oxygenase of the family encoded by the HMOX1 gene (also known as hEAt shock protein 32), is found in human spleen, liver, and kidney. Expression of HO-1 is induced by the presence of heme, hormones, metals, oxidative agents, and drugs as defense against oxidative stress and inflammatory response; its substantially up-regulated activities in a variety of cancers are thought to confer cytoprotective properties from host to cancerous tumors, thus making HO-1 a potential target for cancer therapeutics.4,5,6,7Technical InformationSynonymsHEAt Shock Protein 32Heme Oxygenase-1HMOX1Hsp32Purity90% estimated by SDS-PAGESourceC-terminally histidine-tagged HO-1/HMOX1/Hsp32 human recombinant protein, expressed in E. coliAmino Acids1-265MW31 kDaFormulation50 mM HEPES, pH 8.0, containing 150 mM sodium chlorideUniProt Accession P09601