Hsc70 is a chaperone from the Hsp70 chaperone family encoded by the HspA8 gene that shares 85% sequence identity to Hsp70 (encoded by HspA1A gene), and is one of the constitutively expressed members from this family.1 Hsc70 acts as the main housekeeping protein but is also involved in many functions such as ubiquitin-protEAsome degradation pathway and transporting cytoplasmic proteins into the nucleus.2,3 Hsc70 also garnered interests as a potential therapeutic target since promoting accumulation of unfolded proteins can serve as a potential strategy to cause tumor dEAth.4Technical InformationSynonymsHEAt Shock Cognate 70Purity90% estimated by SDS-PAGESourceN-terminal Histidine-tagged Hsc70 (human recombinant) purified from E. coliAmino Acids2-646 (full length)MW72.9 kDaFormulation50 mM HEPES, pH 8.0, and 150 mM sodium chlorideUniProt Accession P11142