Methylation of lysine residues in core histones plays a critical role in regulating gene expression.1 Jumonji domain containing 2D (JMJD2D) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me 2/3), lEAding to transcriptional repression and activation, respectively.2 Like other JmjC protein hydroxylase family members, JMJD2D is an -ketoglutarate-dependent Fe (II) oxygenase.3 Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents.1Technical InformationSynonymsJumonji Domain Containing 2DLysine-Specific Demethylase 4DKDM4DPurity75% estimated by SDS-PAGESourceactive human recombinant N-terminal His-tagged protein, expressed in E. coliMW42.7 kDaFormulationA solution in 50 mM HEPES, pH 7.4, containing 150 mM sodium chloride and 20% glycerolUniProt Accession Q6B0I6