Biological detergents are commonly used to disrupt the bipolar lipid membrane of cells in order to release and solubilize membranebound proteins. Some detergents can be used to solubilize recombinant proteins, while others are recommended for the stabilization, crystallization, or denaturation of proteins.Detergents in Hematology Analyzers are used to dilute blood samples & to keep the blood cell in original volume completely within a certain period. The Detergent should guarantee pulse obtained corresponding to the cell volume by appropriate conductivity.