SupelSwift HLB is a co-polymer solid phase extraction (SPE) phase composed of both hydrophilic and lipophilic functional groups. This phase is ideal for extracting a broad range of compounds from aqueous samples, including food and environmental samples, as well as biological samples (eg. serum and plasma). Because of the hydrophilic and lipophilic balanced (HLB) property, the polymer material can selectively retain a wide range of compounds with different polarities and LogP values. Traditional HLB SPE uses a five-step process for sample preparation that normally includes the conditioning of sorbents with an organic solvent followed by an equilibration step to return sorbents to sample loading conditions. The product design allows for direct sample loading onto the sorbent bed, thereby eliminating conditioning of the cartridge. This product feature can both save time and simplify sample preparation, which may also serve to reduce sample processing errors.