COX-1 and -2, also called prostaglandin endoperoxide H synthases-1 and -2, are key regulatory enzymes in the prostaglandin biosynthetic pathway. COX enzymes catalyze the committed step in the conversion of arachidonic acid (Item No. 90010) to prostaglandin H2 (Item No. 17020). These enzymes are the major targets for NSAIDs that are used to reduce pain, inflammation, and fever.1 Technical Information Synonyms Cyclooxygenase 1 PGHS-1 Prostaglandin Endoperoxide Synthase 1 Prostaglandin G/H Synthase 1 Prostaglandin H2 Synthase 1 Purity 85% estimated by SDS-PAGE Source Recombinant N-terminal His-tagged protein expressed using the baculovirus system Amino Acids 24-599 (full-length) MW ~70 kDa Formulation 80 mM Tris, pH 8.0, with 0.01% polysorbate 20, 300 M DDC, and 10% glycerol UniProt Accession P23219