Cyclooxygenase (COX)-1 and -2, also called prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and -2) are key regulatory enzymes in the PG biosynthetic pathway. COX enzymes catalyze the committed step in the conversion of arachidonic acid to PGH2(Item No.17020). These enyzmes are the major targets for NSAIDs that are used to reduce pain, inflammation, and fever.1 Technical Information Synonyms Cyclooxygenase 2 Inducible Cyclooxygenase Prostaglandin H Synthase 2 Purity 80% estimated by SDS-PAGE Source recombinant protein expressed in Sf21 cells using the Baculovirus system Amino Acids 24-599 (signal peptide removed) MW ~70 kDa Specific Activity >20,000 U/mg (minimum) UniProt Accession P79208