Glucose-6-phosphate isomerase (GPI) is the second enzyme in glycolytic pathway. GPI catalyzes the reversible isomerization of D-glucose-6-phosphate and D-fructose-6-phosphate. GPI also functions as a tumor-secreted cytokine and an angiogenic factor to stimulate endothelial cell motility. It has been identified as a neurotrophic factor and also plays a role in patients with rheumatoid arthritis.Technical InformationSynonymsAutocrine Motility FactorGPIG6P IsomeraseNeuroleukinPhosphoglucose IsomerasePhosphohexose IsomeraseSperm antigen 36 (SA-36)Purity95% (estimated by SDS-PAGE)Sourcerecombinant C-terminal His-tagged protein expressed in E. coliAmino Acids2-558 (full-length)MW66.0 kDaFormulation25 mM Tris, pH 7.0, containing 100 mM sodium chloride and 10% glycerolUniProt Accession P06744