Tudor domains are small protein structural motifs of ~50 amino acids related to the royal family of methyl rEAders, which also includes chromo, MBT, PWWP, and Agenet-like domains.1,2 Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification, and chromatin remodeling.3 The tudor domains recognize symmetric methylated arginine or methylated lysine residues.4,5,6,7JMJD2C is an -ketoglutarate-dependent Fe (II) oxygenase that catalyzes the demethylation of trimethylated histone H3 at lysine residues 9 and 36 (H3K9me3 and H3K36me3).8 This protein product contains the tandem tudor domains of JMJD2CTechnical InformationSynonymsGASC-1 ProteinKDM4CLysine-specific Demethylase 4CJmjC Domain-containing Histone Demethylation Protein 3CJumonji Domain-containing Protein 2CPurityestimated by SDS-PAGESourcerecombinant N-terminal GST-tagged protein expressed in E. coliMW39.89 kDaFormulation50 mM Tris, pH 7.5, containing 150 mM sodium chloride and 20% glycerolUniProt Accession Q9H3R0OriginAnimal/Rabbit