SRT1720 Hydrochloride, 25 mg
- Brand: Biorbyt
- Catalog No.: orb322204-25mg
- CAS No: 1001645-58-4
- Quantity/Unit: 25 mg/Pack
- Availability: In stock
Min Orderable Qty : 1 Pack
For lab/research use only, unless otherwise specified
SRT1720 is an inhibitor of sirtuin 3 (SIRT3) and activator of sirtuin 1 (SIRT1); sirtuins are considered class III histone deacetylases (HDACs). SRT1720 exhibits nephroprotective, anti-aging, anti-inflammatory, and pro-angiogenic activities. SRT1720 binds the acetyl-Lys site on sirtuins rather than the NAD+ site. In animal models of kidney ischemia/reperfusion injury, SRT1720 improves renal tubular pathology and overall renal function. In animal models fed high fat diets, SRT1720 delays the onset of metabolic diseases and decreases levels of pro-inflammatory cytokines, extending animal lifespan. In animal models of macular degeneration, this compound suppresses activation of NF-B and release of IL-6, IL-8, and MMP-9, decreasing amyloid- (A)-induced retinal pigment epithelial barrier disruption. Additionally, SRT1720 increases VEGF secretion and promotes migration and metastasis of breast cancer cells in vitro and in vivo.; Purity: 98%; Molecular Weight: 506.02, 25 mg
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Seller 1 | ₹ 1,42,324.00 | Min Orderable Qty: 1 Pack |