11-Hydroxysteroid Dehydrogenase (Type 2) Blocking Peptide-10242

11-Hydroxysteroid Dehydrogenase (Type 2) Blocking Peptide-10242

₹ 14,124.00 *
  • Brand: Cayman Chemical
  • Catalog No.: 10242
  • Quantity/Unit: 200 µg/Pack
  • Shipping timeline will be mentioned in quote

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Min Orderable Qty : 1 Pack

For lab/research use only, unless otherwise specified


11-Hydroxysteroid dehydrogenase type 2 (11-HSD2) plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess.1 Expression of 11-HSD2 mRNA and protein has been shown in placenta and mineralocorticoid target tissues, particularly the kidney.2 In mouse, expression of this enzyme is tissue- and developmentally specific, indicating the importance of the enzyme in regulating glucocorticoid-mediated maturation.3 Caymans 11-HSD2 polyclonal antibody detects a band at around 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells.