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BRD2 bromodomains 1 and 2 (human recombinant)

BRD2 bromodomains 1 and 2 (human recombinant)

₹ 37,620.00 *
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  • Brand: Cayman Chemical
  • Catalog No.: 11069
  • Quantity/Unit: 100 ug/Pack
  • Shipping timeline will be mentioned in quote

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Min Orderable Qty : 1 Pack


For lab/research use only, unless otherwise specified

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Key FEAtures Caymans BRD2 bromodomains 1 and 2 TR-FRET Assay Kit (Item No. 600810) was developed using BRD2 bromodomain 1 and 2 (human recombinant) protein. Bulk sizes available upon request The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.1 These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT.2 The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions.3,4,5 The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.6,7,8,9,4 Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disEAse.10,11,12 Technical Information Synonyms Bromodomain containing protein 2 RING3 RNF3 Purity 90% estimated by SDS-PAGE Source recombinant GST-tagged protein expressed in E. coli MW 71.2 kDa Formulation 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM -mercaptoethanol UniProt Accession P25440