Fostamatinib, 25 mg
₹ 76,398.00 *
- Brand: Biorbyt
- Catalog No.: orb1227128-25mg
- CAS No: 1025687-58-4
- Quantity/Unit: 25 mg/Pack
- Availability: In stock
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Min Orderable Qty : 1 Pack
For lab/research use only, unless otherwise specified
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Fostamatinib (R788 disodium salt) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM; dose-dependently inhibits anti-IgE-mediated CHMC degranulation with an EC50 of 56 nM, inhibits all phosphorylation events downstream of Syk signaling; specifically inhibits FcR signaling in human mast cells, macrophages, and neutrophils. R788 can inhibit local inflammatory injury mediated by immune complexes; reduces immune complex-mediated inflammation in arthritis models. Rheumatoid ArthritisPhase 3 Clinical; Purity: >98% (HPLC); Molecular Weight: 624.4232, 25 mg
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