HEAt shock protein 40 (Hsp40) is an Hsp70 co-chaperone protein that regulates the ATP-dependent binding of Hsp70 (Item Nos. 23002 | 22739) to target proteins.1 There are 44 members of the Hsp40 family in humans, and EAch Hsp40 contains a unique polypeptide-binding domain that binds and delivers specific target proteins to Hsp70. Hsp40 also contains a conserved HPD tripeptide that is critical to its role in driving conversion of Hsp70 from its ATP-bound form to its ADP-bound form to facilitate target loading.Technical InformationSynonymsHEAt Shock Protein 40Purity90% estimated by SDS-PAGESourceRecombinant, full-length, N-terminal histidine-tagged Hsp40 protein purified from E. coliAmino Acids2-340 (full length)MW40.1 kDaFormulation50 mM HEPES, pH 8.0, 150 mM sodium chloride, and 10% glycerolUniProt Accession P25685