Intended Use: IL-s Fast Test Kit (Immunofluoresence Assayi is intented for in vitro quantitative determination of interleu kin 6 (IL-6) in human serum, plasma, whole blod and peripheral blood samples. IL-6 is an early maker in acute inflammation and this test can be used as an aid in the inllammatory diseases. Summary: IL-6 is a cytokine that functions in inflammation and maturation of B calls. The protein is primanly produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response. This classical responsivness to IL-6 is governed by a receptor complex consisting of two membrane-bound subunits, an 80 Da cognate Alpha-chain (IL-6R Alpha), and a ubiquitously expressed 130-KDa Beta-chain receptor (gp130) which acts as the universal signal transducing element for all IL-6 family cytokines. Many different cells are capable of IL-6 synthesis including monocytes/macrophages, fibroblasts. endothelial cells, keratinocytes, mast cels. T cells and many tumor cell lines. In vivo and in vitro, IL-6 acts as a differentiation factor for B cells and an activation factor for T cels [L-6 is a patent growth factor of different human myelomas and is active in concentration less than 10 pg/mL. IL-3 and IL-6 show in vitro synergistic effects in the differentiation of hemalopoietic progenitor cells. Elevated IL-6 serum or plasma levels may ocour in different diseases including sepsis, autoimmune diseases, lymphomas, AIDS, alonelic liver disease and in patients with infections, or transplant rejection.