Protein arginine methyltransferases (PRMTs) are a family of enzymes with highly conserved catalytic domains that catalyze the transfer of a methyl group from S-adenosyl-L-methionine to a specific arginine residue in a target protein. PRMT6 is a nuclEAr type-1 PRMT, catalyzing the formation of -NG-monomethylarginine and asymmetric -NG,NG-dimethylarginine on both histone and non-histone targets.1,2,3 Histone H3 methylation of arginine 2 (H3R2) is a repressive transcriptional mark primarily catalyzed by PRMT6.4 H3R2 dimethylation antagonizes the binding of effector proteins sensitive to H3K4 methylation, such as the Mixed LinEAge Leukemia complex methyltransferase.5 Non-histone targets of PRMT6 include the nuclEAr high-mobility group protein HMGA1a, a protein important in several processes relating to the maintenance of DNA integrity.3Technical InformationSynonymsHistone Arginine N-methyltransferase PRMT6HRMT1L6Protein Arginine Methyltransferase 6Purity60%SourceRecombinant N-terminal His-tagged protein expressed in Sf21 cellsMW43.7 kDaFormulation50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride, and 20% glycerolUniProt Accession Q96LA8