Sildenafil Citrate, 1 g
- Brand: Biorbyt
- Catalog No.: orb864230-1g
- CAS No: 171599-83-0
- Quantity/Unit: 1 g/Pack
- Availability: In stock
Min Orderable Qty : 1 Pack
For lab/research use only, unless otherwise specified
Sildenafil is a phosphodiesterase 5 and 6 (PDE5, PDE6) inhibitor that is clinically used to treat erectile dysfunction and pulmonary arterial hypertension. Sildenafil exhibits antihypertensive (through vasodilatory action), antioxidative, and anti-inflammatory activities. In mouse models of sickle cell anemia, sildenafil promotes eNOS activation and inhibits NADPH oxidase, decreasing oxidative stress. In other animal models, sildenafil decreases Iba-1, IFN-, and IL-1 levels and increases glutathione levels, improving myelin structure. This compound also decreases iNOS, TNF-, and caspase-3 expression in vivo. Additionally, sildenafil restores phosphorylation of smad1/5 and expression of inhibitor of DNA binding protein 1 in animals, preventing vascular remodeling and the development of pulmonary hypertension and potentiating bone morphogenetic protein signaling.; Purity: 99%; Molecular Weight: 666.7, 1 g
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Seller 1 | ₹ 1,30,662.00 | Min Orderable Qty: 1 Pack |